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Organocatalytic Enantioselective Synthesis of 1,4‐Dihydropyridines
Author(s) -
AuriaLuna Fernando,
MarquésLópez Eugenia,
Herrera Raquel P.
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700300
Subject(s) - enantioselective synthesis , pharmacophore , chemistry , dhps , organocatalysis , optically active , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , malaria , immunology , plasmodium falciparum , biology
This review aims to bring light upon a very interesting group of compounds, the 1,4‐dihydropyridines (1,4‐DHPs). These structures are well‐known pharmacophores, used for many years to treat cardiovascular diseases because of their activity as calcium channel blockers. In addition, their potential as drugs to treat other affections has been recently exposed. The racemic synthesis of 1,4‐DHPs has been well studied, while the asymmetric approaches are mainly based on the use of chiral auxiliaries or chiral resolutions. However, there are scarce examples regarding enantioselective organocatalytic methods. Herein, we will summarize the existing examples in this field of research.