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Palladium‐Catalyzed Direct β‐C−H Arylation of Ketones with Arylboronic Acids in Water
Author(s) -
Hu Xiaoyun,
Yang Xiaobo,
Dai XiJie,
Li ChaoJun
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700277
Subject(s) - chemistry , palladium , catalysis , aryl , nucleophile , combinatorial chemistry , organic chemistry , alkyl
A palladium‐catalyzed direct β‐C−H arylation of ketones was developed under mild conditions in water, featuring commercially available arylboronic acids as nucleophilic aryl sources and o ‐iodoxybenzoic acid as the oxidant. The method provides a concise route to access β‐arylated ketones. Preliminary studies indicated that direct asymmetric β‐C−H arylation of ketones could be achieved by this strategy.