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Guanidinium Hydroiodide/Cumene Hydroperoxide‐Mediated Intermolecular Oxidative Coupling Reaction of β–Ketoamides with Oxindoles
Author(s) -
Kato Takanari,
Yasui Koji,
Odagi Minami,
Nagasawa Kazuo
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700266
Subject(s) - chemistry , cumene hydroperoxide , intermolecular force , catalysis , oxidative coupling of methane , yield (engineering) , cumene , coupling reaction , derivative (finance) , oxidative phosphorylation , photochemistry , medicinal chemistry , organic chemistry , polymer chemistry , molecule , biochemistry , materials science , economics , financial economics , metallurgy
The first catalytic intermolecular oxidative cross‐coupling reaction between two different carbonyl compounds was achieved by using cumene hydroperoxide as an environmentally friendly, mild oxidant in the presence of a cyclic guanidinium hydroiodide derivative as a catalyst. Cross‐coupling reaction between variouβ ketoamides and oxindoles took place smoothly, and the corresponding 1,4‐dicarbonyl compounds were obtained in 80–99% yield.