General Entry into  o ‐, o′ ‐Heteroatom‐Linked  N ‐(Hetero)aryl‐Imidazole Motifs by Gold‐Catalysed Formal [3+2]‐Dipolar Cycloaddition | Zendy

Garzón Miguel | Zendy; Arce Elsa M. | Zendy; Reddy Raju Jannapu | Zendy; Davies Paul W. | Zendy

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General Entry into o ‐, o′ ‐Heteroatom‐Linked N ‐(Hetero)aryl‐Imidazole Motifs by Gold‐Catalysed Formal [3+2]‐Dipolar Cycloaddition

Author(s) -

Garzón Miguel,

Arce Elsa M.,

Reddy Raju Jannapu,

Davies Paul W.

Publication year - 2017

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201700249

Subject(s) - chemistry , heteroatom , pyridinium , imidazole , aryl , cycloaddition , combinatorial chemistry , redox , stereochemistry , intramolecular force , medicinal chemistry , catalysis , organic chemistry , ring (chemistry) , alkyl

A general redox‐neutral approach into the o ‐, o ′‐heteroatom‐linked N ‐(hetero)aryl‐imidazole family of heteroaromatics has been developed. New types of heteroatom substituted carbimidoyl nitrenoids are efficiently realised from robust, bench‐stable N ‐(heteroaryl)‐pyridinium‐ N ‐aminides by formal gold‐catalysed [3+2]‐dipolar cycloadditions across ynamides. Broad structural variety and functional group tolerance allows rapid access into diverse functionalised scaffolds, as exemplified by the preparation of 8 different heteroaromatic cores.

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