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Copper‐Catalyzed One‐pot Synthesis of Pyrimidines from Amides, N , N ′‐dimethylformamide dimethylacetal, and Enamines
Author(s) -
Jalani Hitesh B.,
Cai Wangshui,
Lu Hongjian
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700234
Subject(s) - chemistry , annulation , catalysis , pyrimidine , dimethylformamide , one pot synthesis , combinatorial chemistry , copper , organic chemistry , medicinal chemistry , stereochemistry , solvent
A versatile copper catalyzed one‐pot synthesis of diversely substituted pyrimidines directly from amides, N , N ′‐dimethylformamide dimethylacetal (DMF−DMA) and enamines has been established. The reaction involved the two C−N bonds and one C−C bond formation by formal [2+1+3] annulation approach to pyrimidines. This protocol is based on the use of readily available primary amides, DMF−DMA and enamines to install di‐ and tri‐substituted pyrimidine structure with diverse functionality in one‐pot manner, which makes this strategy to be appealing for the medicinal chemistry.

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