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Metal‐Free Synthesis of Pyrazoles from 1,3‐Diarylpropenes and Hydrazines via Multiple Inter‐/Intramolecular C–H Aminations
Author(s) -
Tang Li,
Ma Minyan,
Zhang Qi,
Luo Huan,
Wang Tao,
Chai Yonghai
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700196
Subject(s) - chemistry , intramolecular force , combinatorial chemistry , metal , pyrazole , organic chemistry
A facile and metal‐free access to pyrazoles from 1,3‐diarylpropenes and hydrazines via multiple inter‐/intramolecular C‐H aminations was described. Under the neutral and mild 2,3‐dichloro‐5,6‐dicyanobenzoquinone (DDQ) oxidative conditions, various disubstituted pyrazoles were synthesized in moderate to excellent yields. This method provides a pot‐ and step‐economic strategy for the construction of pyrazoles, especially those for drug discovery.