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Front Cover Picture: Late‐Stage Diversification of Non‐Steroidal Anti‐Inflammatory Drugs by Transition Metal‐Catalyzed C–H Alkenylations, Thiolations and Selenylations (Adv. Synth. Catal. 6/2017)
Author(s) -
Ma Wenbo,
Dong Hongbo,
Wang Daoxin,
Ackermann Lutz
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700173
Subject(s) - chemistry , front cover , ackermann function , catalysis , palladium , selectivity , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , cover (algebra) , mechanical engineering , engineering , inverse , geometry , mathematics
The front cover image provided by Wenbo Ma and Lutz Ackermann, illustrates the ruthenium‐ and silver‐catalyzed selective C–H alkenylations, thiolations and selenylations of phenazones with alkenes, disulfides and diselenides. These transformations could be applied to a wide range of substrates and proceed with excellent levels of chemo‐ and site‐selectivity as well as high functional group tolerance. The power of the C–H functionalization strategy was also reflected by late‐stage diversification to access selectively substituted pyrazolones with diverse pharmacological activities. Further details can be found in the full paper on page 966–973 (W. Ma, H. Dong, D. Wang, L. Ackermann, Adv. Synth. Catal . 2017 , 359 , 966–973 (DOI: 10.1002/adsc.201600937)