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Intramolecular C−H Alkenylation of N ‐Alkynylindoles: Exo and Endo Selective Cyclization According to the Choice of Metal Catalyst
Author(s) -
Shibata Takanori,
Baba Takumi,
Takano Hideaki,
Kanyiva Kyalo Stephen
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700107
Subject(s) - chemistry , intramolecular force , iridium , rhodium , catalysis , dig , medicinal chemistry , metal , stereochemistry , cleavage (geology) , bond cleavage , organic chemistry , computer security , geotechnical engineering , fracture (geology) , computer science , engineering
Abstract The intramolecular reaction of 3‐acetyl‐ N ‐alkynylindoles proceeded via C−H bond cleavage at the C2 position. Iridium and rhodium catalysts selectively promoted 6‐ exo ‐dig and 7‐ endo ‐dig cyclization, respectively, and N ‐fused tricyclic compounds were obtained.