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A Biocatalytic Route to Highly Enantioenriched β‐Hydroxydioxinones
Author(s) -
Betori Rick C.,
Miller Eric R.,
Scheidt Karl A.
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700095
Subject(s) - chemistry , scope (computer science) , enantioselective synthesis , diversification (marketing strategy) , scalability , biochemical engineering , substrate (aquarium) , combinatorial chemistry , nanotechnology , organic chemistry , catalysis , computer science , database , engineering , oceanography , materials science , marketing , business , programming language , geology
A novel biocatalytic system to access a wide variety of β‐hydroxydioxinones from β‐ketodioxinones employing commercial engineered ketoreductases has been developed. This practical system provides a remarkably straightforward solution to limitations in accessing certain chemical scaffolds common in β‐hydroxydioxinones that are of great interest due to their diversification capabilities. A few highlights of this system are that it is high yielding, highly enantioselective, and chromatography‐free. We have demonstrated both a wide substrate scope and a high degree of scalability.