A Biocatalytic Route to Highly Enantioenriched β‐Hydroxydioxinones | Zendy

Betori Rick C. | Zendy; Miller Eric R. | Zendy; Scheidt Karl A. | Zendy

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A Biocatalytic Route to Highly Enantioenriched β‐Hydroxydioxinones

Author(s) -

Betori Rick C.,

Miller Eric R.,

Scheidt Karl A.

Publication year - 2017

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201700095

Subject(s) - chemistry , enantioselective synthesis , scope (computer science) , diversification (marketing strategy) , scalability , substrate (aquarium) , nanotechnology , biochemical engineering , combinatorial chemistry , biocatalysis , catalysis , organic chemistry , computer science , reaction mechanism , database , engineering , oceanography , materials science , marketing , business , programming language , geology

A novel biocatalytic system to access a wide variety of β‐hydroxydioxinones from β‐ketodioxinones employing commercial engineered ketoreductases has been developed. This practical system provides a remarkably straightforward solution to limitations in accessing certain chemical scaffolds common in β‐hydroxydioxinones that are of great interest due to their diversification capabilities. A few highlights of this system are that it is high yielding, highly enantioselective, and chromatography‐free. We have demonstrated both a wide substrate scope and a high degree of scalability.

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