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Auto‐Tandem Catalysis‐Induced Synthesis of Trisubstituted Furans through Domino Acid‐Acid‐Catalyzed Reaction of Aliphatic Aldehydes and 1,3‐Dicarbonyl Compounds by using N ‐Bromosuccinimide as Oxidant
Author(s) -
Huang Wenbo,
Liu Changhui,
Gu Yanlong
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700074
Subject(s) - chemistry , tandem , catalysis , n bromosuccinimide , cascade reaction , furan , domino , organic chemistry , reaction conditions , chloride , combinatorial chemistry , halogenation , materials science , composite material
A simple aluminium(III) chloride‐catalyzed synthesis of tri‐substituted furans from aliphatic aldehydes and 1,3‐dicarbonyl compounds was developed by using N ‐bromosuccinimide (NBS) as an oxidant. This method was effective for the synthesis of various furan derivatives. Some of the products were not accessible with the previously reported methods. Mechanically, this reaction involved an auto‐tandem catalysis based on a newly reported acid‐acid‐catalyzed tandem reaction to ensure that furans were successfully synthesized.