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Molybdenum‐Catalyzed Deoxygenation of Heteroaromatic N‐ Oxides and Hydroxides using Pinacol as Reducing Agent
Author(s) -
RubioPresa Rubén,
FernándezRodríguez Manuel A.,
Pedrosa María R.,
Arnáiz Francisco J.,
Sanz Roberto
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700071
Subject(s) - deoxygenation , chemistry , catalysis , environmentally friendly , pinacol , acetone , pyridine , molybdenum , reducing agent , organic chemistry , combinatorial chemistry , ecology , biology
A molybdenum‐catalyzed deoxygenation of pyridine N ‐oxides and N ‐hydroxybenzotriazoles, as well as other azole N ‐oxides, has been developed using pinacol as an environmentally friendly oxo‐acceptor. The only by‐products are acetone and water making the process a convenient alternative to established protocols in terms of waste generation. The reaction is highly chemoselective and a variety of functional groups are tolerated. The processes are usually very clean allowing the isolation of the pure deoxygenated products after a simple extraction in most cases.