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Transition Metal‐Free Iodosobenzene‐Promoted Direct Oxidative 3‐Arylation of Quinoxalin‐2( H )‐ones with Arylhydrazines
Author(s) -
Paul Sanjay,
Ha Ji Hyeon,
Park Ga Eul,
Lee Yong Rok
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700070
Subject(s) - chemistry , transition metal , combinatorial chemistry , oxidative phosphorylation , functional group , reaction conditions , medicinal chemistry , organic chemistry , catalysis , biochemistry , polymer
A transition metal‐free iodosobenzene‐promoted direct oxidative 3‐arylation of quinoxalin‐2( H )‐ones was developed using various arylhydrazines under air. The protocol affords a variety of 3‐arylquinoxalin‐2( H )‐one derivatives in moderate to good yields. This method provides a rapid access to biologically interesting benzo[ g ]quinoxalinones and pyrido[3,4‐ b ]pyrazinones. The present methodology features high functional group tolerance including base‐sensitive groups as well as allyl‐ and benzyl‐substituted quinoxalin‐2( H )‐ones under mild reaction conditions.