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Intramolecular Direct Arylation of 1,3‐Diketone‐Derived Enol Ethers in a Synthesis of Tricyclic Oxoisochromene Derivatives
Author(s) -
Muimhneacháin Eoin Ó,
Pardo Leticia M.,
Bateman Lorraine M.,
Rao Khandavilli U. B.,
Lawrence Simon E.,
McGlacken Gerard P.
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700062
Subject(s) - chemistry , intramolecular force , tricyclic , enol , ketone , diketone , palladium , medicinal chemistry , deuterium , stereochemistry , organic chemistry , catalysis , physics , quantum mechanics
A synthesis of tricyclic oxoisochromene derivatives via an intramolecular direct arylation of cycloalkyl‐1,3‐diketone‐derived α,β‐unsaturated ketone substrates is described. Interesting mechanistic insight has been gathered, based on deuterium migration studies, induced by palladium (Pd).