Copper(I) Oxide/ N , N′ ‐Bis[(2‐furyl)methyl]oxalamide‐Catalyzed Coupling of (Hetero)aryl Halides and Nitrogen Heterocycles at Low Catalytic Loading | Zendy

Pawar Govind Goroba | Zendy; Wu Haibo | Zendy; De Subhadip | Zendy; Ma Dawei | Zendy

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Copper(I) Oxide/ N , N′ ‐Bis[(2‐furyl)methyl]oxalamide‐Catalyzed Coupling of (Hetero)aryl Halides and Nitrogen Heterocycles at Low Catalytic Loading

Author(s) -

Pawar Govind Goroba,

Wu Haibo,

De Subhadip,

Ma Dawei

Publication year - 2017

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201700026

Subject(s) - chemistry , catalysis , halide , aryl , copper , nitrogen , ligand (biochemistry) , oxalic acid , medicinal chemistry , coupling (piping) , combinatorial chemistry , organic chemistry , receptor , biochemistry , alkyl , mechanical engineering , engineering

An easily prepared oxalic diamide is a powerful ligand for the copper‐catalyzed coupling of aryl halides with nitrogen heterocycles. Only 1–2 mol% each of copper(I) oxide and N , N′ ‐bis[(2‐furyl)methyl]oxalamide (BFMO) are needed to form N ‐arylation products under mild conditions. More than 10 different types of nitrogen heterocycles are compatible with these conditions, thereby giving the corresponding N ‐arylation products.

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