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Chiral Squaramide‐Catalyzed Enantioselective Decarboxylative Addition of β‐Keto Acids to Isatin Imines
Author(s) -
Kaur Jasneet,
Kumari Anita,
Bhardwaj Vimal K.,
Chimni Swapandeep Singh
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700011
Subject(s) - squaramide , chemistry , enantioselective synthesis , isatin , yield (engineering) , catalysis , organocatalysis , organic chemistry , combinatorial chemistry , materials science , metallurgy
An efficient chiral squaramide‐catalyzed enantioselective decarboxylative addition reaction of β‐keto acids to isatin imines has been developed. The reaction proceeds smoothly using 20 mol% of organocatalyst to afford the chiral 3‐aminooxindoles in high yield and excellent enantioselectivities.