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Lewis Acid‐Catalyzed C( sp 3 )–C( sp 3 ) Bond Forming Cyclization Reactions for the Synthesis of Tetrahydroprotoberberine Derivatives
Author(s) -
Li Jianjun,
Qin Cong,
Yu Yang,
Fan Huaqiang,
Fu Yiwei,
Li Hao,
Wang Wei
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201601423
Subject(s) - chemistry , annulation , lewis acids and bases , catalysis , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry
An efficient Lewis acid‐catalyzed C( sp 3 )–C( sp 3 ) bond forming annulation reaction has been developed. This strategy serves as a new method for the facile synthesis of tetrahydro‐5 H ‐isoquinolino[2,1‐ g ][1,6]naphthyridine derivatives. A wide range of 2‐methylquinoline‐3‐carbaldehydes and 1,2,3,4‐tetrahydroisoquinolines can be applied for this process to afford structurally diverse tetrahydroprotoberberine derivatives in excellent yields.