Lewis Acid‐Catalyzed C( sp  3 )–C( sp  3 ) Bond Forming Cyclization Reactions for the Synthesis of Tetrahydroprotoberberine Derivatives | Zendy

Li Jianjun | Zendy; Qin Cong | Zendy; Yu Yang | Zendy; Fan Huaqiang | Zendy; Fu Yiwei | Zendy; Li Hao | Zendy; Wang Wei | Zendy

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Lewis Acid‐Catalyzed C( sp 3 )–C( sp 3 ) Bond Forming Cyclization Reactions for the Synthesis of Tetrahydroprotoberberine Derivatives

Author(s) -

Li Jianjun,

Qin Cong,

Yu Yang,

Fan Huaqiang,

Fu Yiwei,

Li Hao,

Wang Wei

Publication year - 2017

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201601423

Subject(s) - chemistry , annulation , lewis acids and bases , catalysis , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry

An efficient Lewis acid‐catalyzed C( sp 3 )–C( sp 3 ) bond forming annulation reaction has been developed. This strategy serves as a new method for the facile synthesis of tetrahydro‐5 H ‐isoquinolino[2,1‐ g ][1,6]naphthyridine derivatives. A wide range of 2‐methylquinoline‐3‐carbaldehydes and 1,2,3,4‐tetrahydroisoquinolines can be applied for this process to afford structurally diverse tetrahydroprotoberberine derivatives in excellent yields.

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