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Synthesis and properties of 5,7‐disubstituted 5,7‐dihydropyrido[2,3‐ b :6,5‐ b ′]diindoles
Author(s) -
Ohlendorf Lars,
Velandia John E. Diaz,
Kónya Krisztina,
Ehlers Peter,
Villinger Alexander,
Langer Peter
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201601390
Subject(s) - chemistry , amination , aryl , alkyl , coupling reaction , fluorescence , absorption (acoustics) , combinatorial chemistry , medicinal chemistry , organic chemistry , stereochemistry , catalysis , physics , quantum mechanics , acoustics
A new and efficient two‐step procedure for the preparation of 5,7‐disubstituted 5,7‐dihydropyrido[2,3‐ b :6,5‐ b ′]diindoles, containing aryl‐, benzyl‐ as well as alkyl‐substituents has been developed. This methodology consists of a chemo‐selective double Suzuki‐Miyaura cross‐coupling reaction followed by a fourfold Buchwald‐Hartwig amination reaction. UV/VIS absorption and fluorescence measurements have been carried out for a selected series of compounds. The results are summarized and compared with those of the isomeric 5,7‐disubstituted 5‐7‐dihydropyrido[3,2‐ b :5,6‐ b ′]diindoles.