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Lewis Acid‐Mediated [3+3] Annulation for the Construction of Substituted Pyrimidine and Pyridine Derivatives
Author(s) -
Zhou Yao,
Tang Zhonghe,
Song Qiuling
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201601386
Subject(s) - annulation , chemistry , pyridine , pyrimidine , lewis acids and bases , scope (computer science) , substrate (aquarium) , combinatorial chemistry , organic chemistry , stereochemistry , catalysis , oceanography , computer science , programming language , geology
A direct and single‐step procedure towards substituted pyrimidine and pyridine derivatives via Lewis acid‐promoted [3+3] annulation between 3‐ethoxycyclobutanones and enamines or amidines is presented. Diverse substituted pyrimidine and pyridine derivatives were obtained in good to high yields with a wide substrate scope.