Lewis Acid‐Mediated [3+3] Annulation for the Construction of Substituted Pyrimidine and Pyridine Derivatives | Zendy

Zhou Yao | Zendy; Tang Zhonghe | Zendy; Song Qiuling | Zendy

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Lewis Acid‐Mediated [3+3] Annulation for the Construction of Substituted Pyrimidine and Pyridine Derivatives

Author(s) -

Zhou Yao,

Tang Zhonghe,

Song Qiuling

Publication year - 2017

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201601386

Subject(s) - annulation , chemistry , pyridine , pyrimidine , lewis acids and bases , scope (computer science) , substrate (aquarium) , combinatorial chemistry , organic chemistry , stereochemistry , catalysis , oceanography , computer science , programming language , geology

A direct and single‐step procedure towards substituted pyrimidine and pyridine derivatives via Lewis acid‐promoted [3+3] annulation between 3‐ethoxycyclobutanones and enamines or amidines is presented. Diverse substituted pyrimidine and pyridine derivatives were obtained in good to high yields with a wide substrate scope.

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