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Palladium‐Catalyzed Cyclization of Free Hydroxyalkenoic Acids: Regio‐ and Chemoselective Access to Methylene Lactones
Author(s) -
Mostinski Yelena,
Kotikalapudi Ramesh,
Valerio Viviana,
Nataf Riva,
Tsvelikhovsky Dmitry
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201601346
Subject(s) - chemistry , regioselectivity , palladium , methylene , catalysis , combinatorial chemistry , organic chemistry
A general and collective synthesis of medium‐sized methylene lactones via controlled cyclizations of easily accessible collective precursors is described. The rapid composition of key–hydroxyalkenoic acid scaffold yields an assembly of oxocanones, oxepanones, and pyranones in a regioselective and stereodirected fashion via palladium‐catalyzed cyclization.