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Advances in Organocatalytic 1,6‐Addition Reactions: Enantioselective Construction of Remote Stereogenic Centers
Author(s) -
Chauhan Pankaj,
Kaya Uğur,
Enders Dieter
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201601342
Subject(s) - stereocenter , enantioselective synthesis , chemistry , chirality (physics) , organocatalysis , stereochemistry , combinatorial chemistry , catalysis , organic chemistry , physics , chiral symmetry breaking , quantum mechanics , quark , nambu–jona lasinio model
Due to the competing 1,4‐addition reactions and the distance from the chirality information, the construction of a remote stereogenic center via 1,6‐addition reactions is often regarded as a great challenge in asymmetric synthesis. Recently, the use of organocatalysts has provided new, excellent alternatives to activate the remote δ‐position and facilitate the enantioselective 1,6‐addition reactions. In this regard, different new activation modes have been devised and new types of substrates have been employed. This review describes all the recent developments in this area.