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Front Cover Picture: Copper‐Catalyzed 1,6‐Hydrodifluoroacetylation of para ‐Quinone Methides at Ambient Temperature with Bis(pinacolato)diboron as Reductant (Adv. Synth. Catal. 3/2017)
Author(s) -
Ke Miaolin,
Song Qiuling
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201601340
Subject(s) - chemistry , reagent , quinone , copper , substrate (aquarium) , front cover , cover (algebra) , catalysis , combinatorial chemistry , photochemistry , medicinal chemistry , organic chemistry , mechanical engineering , engineering , oceanography , geology
The front cover image , provided by Qiuling Song, illustrates an original and efficient copper‐catalyzed 1,6‐hydrodifluoroacetylation of para ‐quinone methides with difluoroalkyl bromides with B 2 pin 2 as reductant. In this reaction, a new C( sp 3 )–CF 2 bond was constructed under very mild conditions. Broad substrate scope with para ‐quinone methides ( p ‐QMs) and ambient reaction temperature make this protocol very practical and attractive. Preliminary mechanistic studies manifested that a difluoroalkyl radical pathway was involved in this reaction. Also, the existence of the diboron reagent was an essential requisite for this transformation. Details can be found in the communication on pages 384–389 (M. Ke, Q. Song, Adv. Synth. Catal . 2017 , 359 , 384–389; DOI: 10.1002/adsc.201600991).