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Practical Access to Difluoromethyl Ketones via Straightforward Decarboxylative Difluorination of β‐Ketoacids
Author(s) -
Li YinLong,
Li Jian,
Deng Jun
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201601315
Subject(s) - chemistry , catalysis , combinatorial chemistry , organic chemistry
A facile synthetic approach to a series of difluoromethyl ketones from β‐ketoacids has been described. This transformation is achieved through the straightforward decarboxylative difluorination of β‐ketoacids in the absence of any catalyst. Furthermore, the resulted difluoromethyl ketones can be easily converted into corresponding difluoromethylated building blocks for pharmaceuticals and materials.