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Rhodium(III)‐Catalyzed Controllable C−H Bond Functionalization of Benzamides and Vinylidenecyclopropanes: A Directing Group Determined Reaction Pathway
Author(s) -
Ji Cheng,
Xu Qin,
Shi Min
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201601308
Subject(s) - chemistry , rhodium , catalysis , surface modification , substrate (aquarium) , group (periodic table) , medicinal chemistry , combinatorial chemistry , scope (computer science) , stereochemistry , organic chemistry , oceanography , geology , computer science , programming language
A controllable rhodium(III)‐catalyzed C−H bond activation of benzamides and vinylidenecyclopropanes (VDCPs) by changing the directing group from C(O)NH–OPiv to C(O)NH–OBoc has been disclosed, affording two different major products in good yields under mild condition, respectively. The substrate scope has been investigated and a plausible reaction mechanism has been also proposed on the basis of previous literature.