One‐Pot Assembly of Highly Functionalized Cyclopenta[ b ]pyrroles  via  a Calcium(II)‐ and Copper(II)‐Catalyzed Reaction Sequence | Zendy

Marin Lucile | Zendy; Gandon Vincent | Zendy; Schulz Emmanuelle | Zendy; Lebœuf David | Zendy

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One‐Pot Assembly of Highly Functionalized Cyclopenta[ b ]pyrroles via a Calcium(II)‐ and Copper(II)‐Catalyzed Reaction Sequence

Author(s) -

Marin Lucile,

Gandon Vincent,

Schulz Emmanuelle,

Lebœuf David

Publication year - 2017

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201601301

Subject(s) - chemistry , hydroamination , isomerization , catalysis , copper , combinatorial chemistry , sequence (biology) , medicinal chemistry , organic chemistry , stereochemistry , biochemistry

A user‐friendly, calcium(II)‐ and copper(II)‐catalyzed one‐pot reaction sequence to furnish cyclopenta[ b ]pyrroles with a high level of complexity is depicted. The reaction involves the following sequential transformations: (i) an aza‐Piancatelli cyclization, (ii) a hydroamination/isomerization process and (iii) a subsequent Friedel–Crafts‐type reaction to afford the desired compounds from readily available 2‐furylcarbinols, anilines and secondary alcohols with a minimum of precautions.

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