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Synthesis of 2‐Substituted Quinolines via Rhodium(III)‐Catalyzed C–H Activation of Imidamides and Coupling with Cyclopropanols
Author(s) -
Zhou Xukai,
Qi Zisong,
Yu Songjie,
Kong Lingheng,
Li Yang,
Tian WanFa,
Li Xingwei
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201601278
Subject(s) - chemistry , synthon , bifunctional , rhodium , catalysis , cleavage (geology) , bond cleavage , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , engineering , geotechnical engineering , fracture (geology)
An efficient synthesis of 2‐substituted quinolines from readily available cyclopropanols and imidamides has been developed, where the cyclopropanol acts as a C 3 synthon. With the assistance of a bifunctional imidamide directing group, the reaction occurred via sequential C–H/C–C cleavage and C–C/C–N bond formation.