Synthesis of 2‐Substituted Quinolines  via  Rhodium(III)‐Catalyzed C–H Activation of Imidamides and Coupling with Cyclopropanols | Zendy

Zhou Xukai | Zendy; Qi Zisong | Zendy; Yu Songjie | Zendy; Kong Lingheng | Zendy; Li Yang | Zendy; Tian WanFa | Zendy; Li Xingwei | Zendy

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Synthesis of 2‐Substituted Quinolines via Rhodium(III)‐Catalyzed C–H Activation of Imidamides and Coupling with Cyclopropanols

Author(s) -

Zhou Xukai,

Qi Zisong,

Yu Songjie,

Kong Lingheng,

Li Yang,

Tian WanFa,

Li Xingwei

Publication year - 2017

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201601278

Subject(s) - chemistry , synthon , bifunctional , rhodium , catalysis , cleavage (geology) , bond cleavage , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , engineering , geotechnical engineering , fracture (geology)

An efficient synthesis of 2‐substituted quinolines from readily available cyclopropanols and imidamides has been developed, where the cyclopropanol acts as a C 3 synthon. With the assistance of a bifunctional imidamide directing group, the reaction occurred via sequential C–H/C–C cleavage and C–C/C–N bond formation.

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