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Regioselective Direct C3‐Phosphorylation of N ‐Sulfonylindoles under Mild Oxidative Conditions
Author(s) -
Su Feng,
Lin Weidong,
Zhu Pengfei,
He Dezhi,
Lin Jianbin,
Zhang HuiJun,
Wen TingBin
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201601204
Subject(s) - chemistry , regioselectivity , oxidative phosphorylation , phosphine , peroxide , transformation (genetics) , combinatorial chemistry , medicinal chemistry , organic chemistry , catalysis , biochemistry , gene
The reactions of N ‐sulfonylindoles with H‐phosphine oxides under oxidative conditions give a wide range of C‐3 phosphorylated free (NH)‐indoles. Several mild oxidants, such as AgNO 3 , di‐ tert ‐butyl peroxide (DTBP), and K 2 S 2 O 8 , can be used to promote this transformation.