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Advances in Asymmetric Diastereodivergent Catalysis
Author(s) -
Bihani Manisha,
Zhao John C.G.
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201601188
Subject(s) - stereocenter , diastereomer , chemistry , context (archaeology) , enantioselective synthesis , catalysis , combinatorial chemistry , stereoselectivity , stereochemistry , nanotechnology , organic chemistry , materials science , paleontology , biology
Because the biological and/or pharmacological properties of a given molecule often depend on the absolute and relative configurations of the stereogenic centers, different diastereomers may exhibit totally different biological and/or pharmacological activities. Therefore, for compounds containing multiple stereogenic centers, the stereoselective asymmetric synthesis of all of the individual diastereomers, preferably using a catalytic method, is of great interest and importance in organic synthesis and drug discovery. In this context, the development of catalytic diastereodivergent methods is highly desirable, since it provides one of the most efficient ways to access multiple diastereomers from the same substrates. The current review attempts to summarize the developments in the field of asymmetric diastereodivergent catalysis.