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Chelation‐Assisted Palladium‐Catalyzed γ‐Arylation of Aliphatic Carboxylic Acid Derivatives
Author(s) -
Dey Aniruddha,
Pimparkar Sandeep,
Deb Arghya,
Guin Srimanta,
Maiti Debabrata
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201601121
Subject(s) - chemistry , moiety , palladium , chelation , regioselectivity , denticity , catalysis , intramolecular force , carboxylic acid , aryl , combinatorial chemistry , functional group , organic chemistry , metal , alkyl , polymer
A palladium(II)‐catalyzed protocol for the highly regioselective remote γ ‐C–H arylation of aliphatic carboxylic acid has been disclosed. The 8‐aminoquinoline moiety as an intramolecular bidentate chelator was found to be suitable for this γ ‐C–H arylation. Various aryl iodides successfully produced the regioselectively mono‐arylated products with negligible diarylation. Functional group tolerance and easy‐to‐handle reaction conditions make this method attractive.