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Front Cover Picture: Vinyl Sulfonates: A Click Function for Coupling‐and‐Decoupling Chemistry and their Applications (Adv. Synth. Catal. 21/2016)
Author(s) -
Cruz Carlos M.,
OrtegaMuñoz Mariano,
LópezJaramillo F. Javier,
HernándezMateo Fernando,
Blanco Victor,
SantoyoGonzález Francisco
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201601080
Subject(s) - chemistry , nucleophile , front cover , sulfonate , click chemistry , adduct , decoupling (probability) , medicinal chemistry , combinatorial chemistry , organic chemistry , cover (algebra) , catalysis , sodium , mechanical engineering , control engineering , engineering
The front cover image illustrates the new vinyl sulfonate‐based “click” Coupling‐and‐Decoupling methodology by Victor Blanco, Francisco Santoyo‐Gonzalez and co‐workers. The coupling step relies on the click Michael‐type addition of nucleophiles to vinyl sulfonates, while the decoupling involves the cleavage of the resulting sulfonate adducts either through nucleophilic substitution with different nucleophiles (i.e., glutathione) or through hydrolysis. As a representative example, the methodology is applied in the preparation of cleavable multivalent glycosylated systems. Details can be found in the full paper on pages 3394–3413 (C. M. Cruz, M. Ortega‐Muñoz, F. J. López‐Jaramillo, F. Hernández‐Mateo, V. Blanco, F. Santoyo‐González, Adv. Synth. Catal . 2016 , 358 , 3394–3413; DOI: 10.1002/adsc.201600628).