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A Copper‐Benzotriazole‐Based Coordination Polymer Catalyzes the Efficient One‐Pot Synthesis of ( N′ ‐Substituted)‐hydrazo‐4‐aryl‐1,4‐dihydropyridines from Azines
Author(s) -
Kallitsakis Michael,
Loukopoulos Edward,
AbdulSada Alaa,
Tizzard Graham J.,
Coles Simon J.,
Kostakis George E.,
Lykakis Ioannis N.
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201601072
Subject(s) - benzotriazole , chemistry , catalysis , aryl , copper , polymer , combinatorial chemistry , coordination polymer , polymer chemistry , organic chemistry , alkyl
A series of new ( N′ ‐substituted)‐hydrazo‐4‐aryl‐1,4‐dihydropyridines was successfully synthesized via a facile one‐pot catalytic pathway utilizing azines and propiolate esters as starting materials and a one‐dimensional copper benzotriazole‐based coordination polymer as catalyst. In the absence of catalyst, the corresponding 5‐substituted 4,5‐dihydropyrazoles were formed in moderate to high yields. Fine‐tuning of the catalysts allowed us to gain more insights regarding the plausible reaction mechanism.