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Cobalt‐Catalyzed Mild Ring‐Opening Addition of Arenes C−H Bond to 7‐Oxabicyclic Alkenes
Author(s) -
Muralirajan Krishnamoorthy,
Prakash Sekar,
Cheng ChienHong
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201601026
Subject(s) - chemistry , catalysis , protonation , yield (engineering) , cobalt , medicinal chemistry , ring (chemistry) , dehydration , alkene , reaction conditions , oxygen , combinatorial chemistry , organic chemistry , ion , biochemistry , materials science , metallurgy
A mild approach for a Cp*Co(III)‐catalyzed C−H naphthylation of arenes by 7‐oxabicyclic alkenes has been developed. In some cases, intermediate products with a 1,2‐dihydronaphthalen‐1‐ol group have been isolated at room temperature in good yield. The catalytic reaction proceeds via C−H activation, insertion, β ‐oxygen elimination, protonation, and dehydration, respectively. These simple protocols, featuring mild conditions and tolerance of functional groups, exhibit great potential for a variety of synthetic applications.