Cobalt‐Catalyzed Mild Ring‐Opening Addition of Arenes C−H Bond to 7‐Oxabicyclic Alkenes | Zendy

Muralirajan Krishnamoorthy | Zendy; Prakash Sekar | Zendy; Cheng ChienHong | Zendy

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Cobalt‐Catalyzed Mild Ring‐Opening Addition of Arenes C−H Bond to 7‐Oxabicyclic Alkenes

Author(s) -

Muralirajan Krishnamoorthy,

Prakash Sekar,

Cheng ChienHong

Publication year - 2017

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201601026

Subject(s) - chemistry , catalysis , protonation , yield (engineering) , cobalt , medicinal chemistry , ring (chemistry) , dehydration , alkene , reaction conditions , oxygen , combinatorial chemistry , organic chemistry , ion , biochemistry , materials science , metallurgy

A mild approach for a Cp*Co(III)‐catalyzed C−H naphthylation of arenes by 7‐oxabicyclic alkenes has been developed. In some cases, intermediate products with a 1,2‐dihydronaphthalen‐1‐ol group have been isolated at room temperature in good yield. The catalytic reaction proceeds via C−H activation, insertion, β ‐oxygen elimination, protonation, and dehydration, respectively. These simple protocols, featuring mild conditions and tolerance of functional groups, exhibit great potential for a variety of synthetic applications.

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