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Metal–free Decarboxylative Amination: An Alternative Approach Towards Regioselective Synthesis of β‐Carboline N ‐fused Imidazoles
Author(s) -
Singh Dharmender,
Kumar Vipin,
Devi Nisha,
Malakar Chandi C.,
Shankar Ravi,
Singh Virender
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600970
Subject(s) - chemistry , regioselectivity , amination , imidazole , combinatorial chemistry , ring (chemistry) , organic chemistry , reductive amination , catalysis
Abstract Due to significant activity profile and natural abundance of β‐carboline containing alkaloids, β‐carboline N ‐fused imidazole derivatives were designed and iodine assisted efficient approach was formulated for the regioselective synthesis of designed prototypes via decarboxylative amination of natural α‐amino acids with 1‐formyl pyrido[3,4‐ b ]indoles. Additionally, oxidative amination with benzyl amines was also investigated for the synthesis of these β‐carboline D‐ring containing frameworks.