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Copper‐Catalyzed Remote C−H Amination of Quinolines with N ‐Fluorobenzenesulfonimide
Author(s) -
Yin Yao,
Xie Jian,
Huang FengQing,
Qi LianWen,
Zhang Bo
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600947
Subject(s) - amination , chemistry , reagent , combinatorial chemistry , regioselectivity , catalysis , scope (computer science) , substrate (aquarium) , copper , organic chemistry , computer science , oceanography , programming language , geology
A copper‐catalyzed remote C−H amination of 8‐aminoquinoline scaffolds on the C5 position is described. The protocol employs commercially available N ‐fluorobenzenesulfonimide (NFSI) as the amination reagent and shows broad substrate scope, providing various 5‐aminated quinolines in moderate to excellent yields under mild conditions. These reactions feature complete regioselectivity, operational simplicity, and high efficiency.