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Quaternary Ammonium Salt‐Promoted Multi‐Component Reaction in Water: Access to 3‐Alkyl‐2, 3‐Dihydro‐1H‐Isoindolin‐1‐One Derivatives
Author(s) -
Han FuZhong,
Su BoBo,
Jia LiNa,
Wang PengWei,
Hu XiangPing
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600944
Subject(s) - chemistry , alkyl , salt (chemistry) , ammonium , alkylation , ammonia , benzoic acid , component (thermodynamics) , amine gas treating , organic chemistry , medicinal chemistry , catalysis , physics , thermodynamics
A concise synthesis of alkyl‐2,3‐dihydro‐1H‐isoindolin‐1‐one derivatives from 2‐formyl benzoic acid, β‐keto acid, and ammonia or primary amine was developed via a quaternary ammonium salt‐promoted multi‐component sequence of decarboxylative alkylation/lactamization reaction in water, in which the target products were obtained in good to excellent yields.
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