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Benzo[ c ]isothiazole 2‐Oxides: Three‐Dimensional Heterocycles with Cross‐Coupling and Functionalization Potential
Author(s) -
Lamers Philip,
Buglioni Laura,
Koschmieder Steffen,
Chatain Nicolas,
Bolm Carsten
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600823
Subject(s) - isothiazole , chemistry , surface modification , combinatorial chemistry , coupling reaction , coupling (piping) , computational chemistry , organic chemistry , catalysis , mechanical engineering , engineering
Abstract A robust method for the synthesis of benzo[ c ]isothiazole 2‐oxides has been developed providing a range of functionalized derivatives starting from anilines and DMSO. The reaction sequence can be performed on a gram scale and leads to products that can easily be modified by standard cross‐coupling reactions.