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Front Cover Picture: Cobalt‐Catalyzed C−H Functionalizations by Imidate Assistance with Aryl and Alkyl Chlorides (Adv. Synth. Catal. 15/2016)
Author(s) -
Mei Ruhuai,
Ackermann Lutz
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600800
Subject(s) - chemistry , aryl , catalysis , alkyl , cobalt , medicinal chemistry , combinatorial chemistry , organic chemistry , stereochemistry
The front cover image, provided by Torben Rogge, Ruhuai Mei and Lutz Ackermann, illustrates the synthetic utility of cobalt‐catalyzed C–H arylations by oxazoline assistance at ambient temperature. The catalytic system derived from inexpensive Co(acac) 2 and an N‐heterocyclic carbene enabled C–H arylations with ample scope, and proved applicable to difficult C–H alkylations with unactivated primary and secondary alkyl chlorides. The power of the C–H arylation strategy was reflected by C–H activation at 23 °C, and late‐stage diversification to access bioactive biaryls. Details can be found in the full paper on pages 2443–2448 (R. Mei, L. Ackermann, Adv. Synth. Catal . 2016 , 358 , 2443–2448; DOI: 10.1002/adsc.201600384).