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Synthesis of 3,3‐Dihalo‐2‐oxindoles from 2‐Substituted Indoles via Halogenation–Decarboxylation/Desulfonamidation–Oxidation Process
Author(s) -
Jiang Xiaojian,
Zhang Feng,
Yang Junjie,
Yu Pei,
Yi Peng,
Sun Yewei,
Wang Yuqiang
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600771
Subject(s) - decarboxylation , chemistry , halogenation , oxindole , oxidation process , n bromosuccinimide , organic chemistry , combinatorial chemistry , catalysis , engineering , pulp and paper industry
A novel one‐pot reaction which combines halogenation, decarboxylation/desulfonamidation with oxidation has been developed. Diverse valuable 3,3‐dihalo‐2‐oxindole compounds can be produced rapidly and safely with isolated yields of up to 98% under mild conditions.