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Catalyst‐Controlled Regiodivergent Dehydrogenative Heck Reaction of 4‐Arylthiophene/Furan‐3‐Carboxylates
Author(s) -
Gao Shang,
Wu Zijun,
Wu Fei,
Lin Aijun,
Yao Hequan
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600696
Subject(s) - chemistry , catalysis , furan , heck reaction , ruthenium , palladium , palladium catalyst , organic chemistry , combinatorial chemistry
A catalyst‐controlled regiodivergent dehydrogenative Heck reaction of 4‐arylthiophene/furan‐3‐carboxylates has been realized. Use of a palladium catalyst led to the C‐5 alkenylation through electronic palladation, while a ruthenium catalyst favored the C‐2 alkenylation with the assistance of a directing group. This reaction exhibited good to excellent regioselectivities.