N,N ‐Dimethylformamide as a Methylenating Reagent: Synthesis of Heterodiarylmethanes  via  Copper‐Catalyzed Coupling between Imidazo[1,2‐ a ]pyridines and Indoles/ N,N ‐Dimethylaniline | Zendy

Mondal Susmita | Zendy; Samanta Sadhanendu | Zendy; Santra Sougata | Zendy; Bagdi Avik K. | Zendy; Hajra Alakananda | Zendy

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N,N ‐Dimethylformamide as a Methylenating Reagent: Synthesis of Heterodiarylmethanes via Copper‐Catalyzed Coupling between Imidazo[1,2‐ a ]pyridines and Indoles/ N,N ‐Dimethylaniline

Author(s) -

Mondal Susmita,

Samanta Sadhanendu,

Santra Sougata,

Bagdi Avik K.,

Hajra Alakananda

Publication year - 2016

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201600674

Subject(s) - chemistry , reagent , pyridine , catalysis , dimethylformamide , copper , combinatorial chemistry , coupling (piping) , coupling reaction , medicinal chemistry , organic chemistry , mechanical engineering , solvent , engineering

A new copper‐catalyzed, efficient method for the synthesis of heterodiarylmethanes through the coupling of imidazo[1,2‐ a ]pyridines with indoles employing N,N ‐dimethylformamide as a methylenating reagent has been developed. A library of 3‐(1 H ‐indol‐3‐ylmethyl)‐imidazo[1,2‐ a ]pyridine derivatives has been synthesized under aerobic reaction conditions. This protocol is also applicable for the synthesis of (4‐imidazo[1,2‐ a ]pyridin‐3‐ylmethyl)(phenyl)dimethylamines. The method is highly selective for the hetero‐coupling.

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