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Transition Metal‐Free Carbazole Synthesis from Arylureas and Cyclohexanones
Author(s) -
Wu Jun,
Xie Yanjun,
Chen Xiangui,
Deng GuoJun
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600673
Subject(s) - chemistry , carbazole , moiety , transition metal , iodine , iodide , transformation (genetics) , nitrogen atom , combinatorial chemistry , organic chemistry , catalysis , alkyl , biochemistry , gene
An efficient strategy for carbazole synthesis from arylureas and cyclohexanones under transition metal‐free conditions has been developed. The combined use of potassium iodide and iodine could significantly improve the reaction efficiency to provide 2,6‐disubstituted 9‐arylcarbazoles in moderate to good yields. In this kind of transformation, the whole carbazole moiety (except the nitrogen atom) comes from two equivalents of cyclohexanones.