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Direct Phosphorus‐Induced Fluoroalkylthiolation with Fluoroalkylsulfonyl Chlorides
Author(s) -
Jiang Lvqi,
Yi Wenbin,
Liu Qiran
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600651
Subject(s) - chemistry , electrophile , reagent , phosphorus , combinatorial chemistry , medicinal chemistry , organic chemistry , catalysis
A simple and practical method of fluoroalkylthiolation using fluoroalkylsulfonyl chlorides (R f SO 2 Cl, R f =CF 3 , C 4 F 9 , C 8 F 17 , CF 2 H and CH 2 CF 3 ) has been developed. These easy‐to‐handle reagents are powerful and can be used for electrophilic fluoroalkylthiolation of electron‐rich arenes and thiols using diethyl phosphite as reducing agent.