Facile, Efficient and Diastereoselective Construction of Indane‐Fused Pyrrolidin‐2‐ones  via  a Potassium Hydroxide‐Catalyzed Domino Reaction | Zendy

Xing Siyang | Zendy; Ren Jing | Zendy; Wang Kui | Zendy; Cui Hong | Zendy; Xia Tian | Zendy; Zhang Ming | Zendy; Wang Dandan | Zendy

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Facile, Efficient and Diastereoselective Construction of Indane‐Fused Pyrrolidin‐2‐ones via a Potassium Hydroxide‐Catalyzed Domino Reaction

Author(s) -

Xing Siyang,

Ren Jing,

Wang Kui,

Cui Hong,

Xia Tian,

Zhang Ming,

Wang Dandan

Publication year - 2016

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201600611

Subject(s) - indane , chemistry , stereocenter , potassium hydroxide , domino , cascade reaction , catalysis , ring (chemistry) , medicinal chemistry , hydroxide , potassium , combinatorial chemistry , tandem , organic chemistry , enantioselective synthesis , materials science , composite material

A facile and efficient potassium hydroxide (KOH)‐catalyzed tandem reaction involving sequential Michael addition of electron‐deficient alkenes with malonic esters, ring opening of activated aziridines and lactamization has been described. A highly functionalized indane‐fused tricyclic scaffold containing three rings, three adjacent stereocenters and a quaternary center was constructed by the formation of two new C–C bonds and one new C–N bond in a diastereoselective manner.

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