Suzuki Coupling of Amides  via  Palladium‐Catalyzed C–N Cleavage of  N ‐Acylsaccharins | Zendy

Wu Hongxiang | Zendy; Li Yue | Zendy; Cui Ming | Zendy; Jian Junsheng | Zendy; Zeng Zhuo | Zendy

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Suzuki Coupling of Amides via Palladium‐Catalyzed C–N Cleavage of N ‐Acylsaccharins

Author(s) -

Wu Hongxiang,

Li Yue,

Cui Ming,

Jian Junsheng,

Zeng Zhuo

Publication year - 2016

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201600555

Subject(s) - chemistry , palladium , catalysis , aryl , cleavage (geology) , yield (engineering) , alkyl , bond cleavage , medicinal chemistry , palladium catalyst , organic chemistry , polymer chemistry , combinatorial chemistry , materials science , geotechnical engineering , fracture (geology) , engineering , metallurgy

A palladium‐catalyzed cross‐coupling of activated amides with arylboronic acids has been developed via C–N bond cleavage. This approach demonstrated high tolerance to a variety of alkyl, aryl, heterocyclic and vinyl substituents. Unsymmetrical ketones could be achieved in excellent yield under mild conditions with 1% catalyst loadings.

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