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Suzuki Coupling of Amides via Palladium‐Catalyzed C–N Cleavage of N ‐Acylsaccharins
Author(s) -
Wu Hongxiang,
Li Yue,
Cui Ming,
Jian Junsheng,
Zeng Zhuo
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600555
Subject(s) - chemistry , palladium , catalysis , aryl , cleavage (geology) , yield (engineering) , alkyl , bond cleavage , medicinal chemistry , palladium catalyst , organic chemistry , polymer chemistry , combinatorial chemistry , materials science , geotechnical engineering , fracture (geology) , engineering , metallurgy
A palladium‐catalyzed cross‐coupling of activated amides with arylboronic acids has been developed via C–N bond cleavage. This approach demonstrated high tolerance to a variety of alkyl, aryl, heterocyclic and vinyl substituents. Unsymmetrical ketones could be achieved in excellent yield under mild conditions with 1% catalyst loadings.