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Cover Picture: Synthesis of 2 H ‐Indazoles via Tandem Palladium‐Catalyzed Deacylative Cross‐Coupling and Denitrogenative Cyclization of 2‐Iodoazoarenes and 2‐Iodoaryltriazenes with Acyldiazoacetates in One‐Pot (Adv. Synth. Catal. 12/2016)
Author(s) -
Yong WooSoon,
Park Sangjune,
Yun Hyunsik,
Lee Phil Ho
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600524
Subject(s) - chemistry , catalysis , palladium , tandem , one pot synthesis , coupling reaction , combinatorial chemistry , coupling (piping) , reaction conditions , cover (algebra) , medicinal chemistry , stereochemistry , organic chemistry , mechanical engineering , materials science , engineering , composite material
The inside cover picture , provided by Phil Ho Lee and co‐workers, illustrates a synthetic method to prepare a wide range of 2 H ‐indazoles via a tandem Pd‐catalyzed deacylative cross‐coupling reaction of 2‐iodoazoarenes and 2‐iodoaryltriazenes with acyldiazoacetates and denitrogenative cyclization reaction of in situ generated diazoacetates having azoaryl and triazenylaryl moieties in one‐pot. Additionally, azoaryl‐substituted diazoacetates underwent Pd‐catalyzed denitrogenative cyclization to produce 2 H ‐indazoles. The present reaction is a good example in which a Pd(0) catalyst is involved in two catalytic cycles in one‐pot. Details can be found in the full paper on pages 1958–1967 (W.‐S. Yong, S. Park, H. Yun, P. H. Lee, Adv. Synth. Catal. 2016 , 358 , 1958–1967; DOI: 10.1002/adsc.201600351 ).