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Decarboxylative (4+1) Oxidative Annulation of Malonate Monoesters with 2‐Vinylpyridine Derivatives
Author(s) -
Tang Shan,
Gao Xinlong,
Lei Aiwen
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600506
Subject(s) - chemistry , malonate , annulation , indolizine , alkyl , oxidative phosphorylation , combinatorial chemistry , organic chemistry , medicinal chemistry , catalysis , biochemistry
A novel N ‐iodosuccinimide‐mediated decarboxylative (4+1) oxidative annulation between 2‐vinylpyridine derivatives and malonate monoesters was developed. It offers a new way to construct indolizine derivatives by utilizing malonate monoesters as a C 1 unit. The alkyl 2,2‐diiodoacetate was found to be the active reaction intermediate during the transformation.