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Cover Picture: Palladium‐Catalyzed One‐Pot Synthesis of 5‐(1‐Arylvinyl)‐1 H ‐benzimidazoles: Overcoming the Limitation of Acetamide Partners (Adv. Synth. Catal. 11/2016)
Author(s) -
Naret Timothée,
Retailleau Pascal,
Big Jérôme,
Brion JeanDaniel,
Alami Mouad,
Hamze Abdallah
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600491
Subject(s) - chemistry , palladium , acetamide , catalysis , medicinal chemistry , combinatorial chemistry , stereochemistry , cover (algebra) , organic chemistry , mechanical engineering , engineering
The cover picture , provided by Abdallah Hamze and co‐workers, reports an efficient one‐pot metal‐catalyzed process between N ‐tosylhydrazones, N ‐(dihalophenyl)‐imidates, and amines. During this transformation, one CC bond and two CN bonds were created by a single palladium‐catalyzed reaction leading to a library of 5‐(1‐arylvinyl)‐1 H ‐benzimidazoles. Imidates were found to be an ideal partner for the cross‐coupling with hydrazones in comparison with acetamides. Among several derivatives evaluated, one compound exhibits excellent antiproliferative activity in the nanomolar concentration range. Details can be found in the full paper on pages 1833–1847 (T. Naret, P. Retailleau, J. Bignon, J.‐D. Brion, M. Alami, A. Hamze, Adv. Synth. Catal. 2016 , 358 , 1833–1847; DOI: 10.1002/adsc.201600173 ).