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Facile Synthesis of 3‐Halobenzo‐heterocyclic‐2‐carbonyl Compounds via in situ Halogenation‐Oxidation
Author(s) -
Jiang Xiaojian,
Yang Junjie,
Zhang Feng,
Yu Pei,
Yi Peng,
Sun Yewei,
Wang Yuqiang
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600431
Subject(s) - chemistry , halogenation , in situ , organic chemistry , combinatorial chemistry
A facile method to synthesize 3‐halobenzo‐heterocyclic‐2‐carbonyl compounds is described. Mechanistic studies suggested that a halo‐cyclization process, which generated the unstable spiro‐acetal transition state and readily convertible to the corresponding carbonyl compound might be involved. Diverse 3‐halobenzo‐heterocyclic‐2‐carbonyl compounds could be synthesized with up to 95 % yield in mild conditions with inexpensive starting materials.