Synthesis of Tricyclic Isoquinoline Derivatives  via  Palladium‐ Catalyzed Tandem Reactions of 2,7‐Alkadiynylic Carbonates with 2,3‐Allenyl Sulfamides | Zendy

Huang Xin | Zendy; Wu Wangteng | Zendy; Song Shihua | Zendy; Fu Chunling | Zendy; Ma Shengming | Zendy

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Synthesis of Tricyclic Isoquinoline Derivatives via Palladium‐ Catalyzed Tandem Reactions of 2,7‐Alkadiynylic Carbonates with 2,3‐Allenyl Sulfamides

Author(s) -

Huang Xin,

Wu Wangteng,

Song Shihua,

Fu Chunling,

Ma Shengming

Publication year - 2016

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201600406

Subject(s) - isoquinoline , chemistry , tandem , palladium , tricyclic , catalysis , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , materials science , composite material

The palladium‐catalyzed tandem reactions of 2,7‐alkadiynylic carbonates with 2,3‐allenyl sulfamides for the syntheses of fused tricycles such as 1,3,6,7,8,9‐hexahydrofuro[3,4 ‐h ]isoquinoline, 2,3,6,7,8,9‐hexahydro‐1 H ‐pyrrolo[3,4 ‐h ]isoquinoline, and 2,3,4,7,8,9‐hexahydro‐1 H ‐cyclopenta[ h ]isoquinoline derivatives have been developed. A mechanism has been proposed based on the isolation of a by‐product.

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