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Synthesis of Tricyclic Isoquinoline Derivatives via Palladium‐ Catalyzed Tandem Reactions of 2,7‐Alkadiynylic Carbonates with 2,3‐Allenyl Sulfamides
Author(s) -
Huang Xin,
Wu Wangteng,
Song Shihua,
Fu Chunling,
Ma Shengming
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600406
Subject(s) - isoquinoline , chemistry , tandem , palladium , tricyclic , catalysis , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , materials science , composite material
The palladium‐catalyzed tandem reactions of 2,7‐alkadiynylic carbonates with 2,3‐allenyl sulfamides for the syntheses of fused tricycles such as 1,3,6,7,8,9‐hexahydrofuro[3,4 ‐h ]isoquinoline, 2,3,6,7,8,9‐hexahydro‐1 H ‐pyrrolo[3,4 ‐h ]isoquinoline, and 2,3,4,7,8,9‐hexahydro‐1 H ‐cyclopenta[ h ]isoquinoline derivatives have been developed. A mechanism has been proposed based on the isolation of a by‐product.