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Enantioselective Copper‐Catalyzed Intramolecular N−H Bond Insertion: Synthesis of Chiral 2‐Carboxytetrahydroquinolines
Author(s) -
Song XiaoGuang,
Ren YuanYuan,
Zhu ShouFei,
Zhou QiLin
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600390
Subject(s) - enantioselective synthesis , chemistry , intramolecular force , catalysis , copper , yield (engineering) , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , materials science , metallurgy
The first highly enantioselective intramolecular N−H bond insertion was realized by using copper catalysts modified with chiral spirobisoxazoline ligands, which provides a novel strategy for the synthesis of chiral 2‐carboxytetrahydroquinolines. This reaction features fast reaction rate, high yield, high enantioselectivity, and mild reaction conditions.