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Cobalt‐Catalyzed C−H Functionalizations by Imidate Assistance with Aryl and Alkyl Chlorides
Author(s) -
Mei Ruhuai,
Ackermann Lutz
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600384
Subject(s) - chemistry , cobalt , catalysis , aryl , alkyl , ligand (biochemistry) , carbene , combinatorial chemistry , substrate (aquarium) , primary (astronomy) , medicinal chemistry , organic chemistry , biochemistry , receptor , oceanography , physics , astronomy , geology
A catalytic system comprising the inexpensive cobalt(II) acetylacetonate [Co(acac) 2 ] and an N‐heterocyclic carbene (NHC) ligand enabled versatile C−H arylations by oxazoline assistance. The broadly applicable, low‐valent cobalt catalyst displayed a wide substrate scope, and even proved applicable to challenging C−H alkylations with β‐hydrogen‐containing primary and secondary alkyl chlorides. The power of the cobalt‐catalyzed C−H arylation protocol was among others reflected by facile C−H activation at a room temperature of 23 °C, and efficient late‐stage diversification, providing access to bioactive biaryls.